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Abstract #0260

Multiparameter MRI Predictors of Extreme Survival in Glioblastoma Multiforme

Natarajan Raghunand1, Olya Stringfield2, John Arrington3, and Robert A Gatenby3

1Cancer Imaging & Metabolism, Moffitt Cancer Center, Tampa, FL, United States, 2IRAT Shared Service, Moffitt Cancer Center, Tampa, FL, United States, 3Diagnostic Imaging & Interventional Radiology, Moffitt Cancer Center, Tampa, FL, United States

We retrospectively analyzed initial MRI scans in two cohorts diagnosed with Glioblastoma Multiforme (GBM). The Long-Term Survival (LTS) cohort included 13 subjects who survived >36 months post-diagnosis, while the Short-Term Survival (STS) cohort included 12 subjects who survived ≤18 months. Tumor voxels were clustered by the normalized signal intensities on post-contrast T1w and FLAIR sequences into 6 distinct “habitats”. The LTS cohort were found to have a significantly higher fraction of Habitat 6 (high signal on T1w and FLAIR sequences) and lower fraction of Habitat 2 (low signal on T1w and high signal on FLAIR) compared with the STS cohort.

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