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Abstract #0270

Highly sensitive pH mapping during ischemia using Total Fast-exchanging Protons (TFP) imaging

Jiadi Xu1, Kathryn Schunke1,2, Lin Chen1,3, Xiang Xu1, Yuguo Li1, Guanshu Liu1, Shuhui Cai3, Raymond C Koehler2, Jiangyang Zhang4, Peter C. M. van Zijl1, and Nauder Faraday2

1kirby Center / Radiology Department, Kennedy Krieger Institute / Johns Hopkins Univeristy, baltimore, MD, United States, 2Department of Anesthesiology/Critical Care Medicines, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Electronic Science, Xiamen University, Xiamen, People's Republic of China, 4Bernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States

Ischemia in a mouse stroke model was assessed by pH mapping using the on-resonance variable-delay multi-pulse (onVDMP) CEST scheme. In the method, an on-resonance binomial pulse train is applied at the water resonance to achieve high labeling efficiency for fast-exchanging protons. Since the CEST signal intensity for the total fast-exchanging protons is far greater than that of amide protons, high detection sensitivity is expected. The final stroke region determined by the method was verified by histologic analysis.

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