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Abstract #0271

In-vivo Detection of Remote Neurodegeneration within Thalamic Nuclei after Stroke Using Iron Quantification with R2* Mapping

Grégory Kuchcinski1, Fanny Munsch2, Renaud Lopes1, Jason Su3, Antoine Bigourdan2, Brian K. Rutt3, Vincent Dousset2, Igor Sibon4, and Thomas Tourdias2

1Neuroradiology, Univ. Lille, CHU Lille, Lille, France, 2Neuroimagerie diagnostique et thérapeutique, Université de Bordeaux, CHU de Bordeaux, France, 3Richard M. Lucas Center for Imaging Radiology Department, Stanford University, United States, 4Unité neurovasculaire, Université de Bordeaux, CHU de Bordeaux, France

In stroke patients, remote thalamic alterations including iron deposition have been reported and attributed to the disruption of cortico-thalamic projections. Nevertheless, secondary thalamic degeneration has never been quantified so far in humans at the nucleus scale and its clinical impact is unknown. By using R2* mapping, we demonstrated (i) that iron accumulates with a focal distribution especially within the medio-dorsal nucleus and the pulvinar, (ii) that such focal thalamic iron accumulation is strongly linked to the initial stroke location, consistent with the known connectivity between thalamic nuclei and cortico-subcortical areas and (iii) is significantly impacting specific cognitive and emotional functions.

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