Abstract #0277

Time dependence of microscopic anisotropy in the mouse brain measured with double oscillating diffusion encoding (DODE) MRI

Andrada Ianus^1,2, Sune N. Jespersen^3,4, Daniel C. Alexander², Ivana Drobnjak², and Noam Shemesh¹

¹Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal, ²Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, ³Center of Functionally Integrative Neuroscience (CFIN) and MINDLab, Clinical Institute, Aarhus University, Aarhus, Denmark, ⁴Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark

Time dependence of microscopic anisotropy measured with diffusion MRI can reveal the cellular eccentricity at different lengths scales, which is an important step towards the goal of non-invasive characterization of tissue microstructure. Diffusion sequences which vary the gradient orientation within one measurement can probe microscopic anisotropy, regardless of the macroscopic tissue configuration. Here we employ the newly proposed Double Oscillating Diffusion Encoding (DODE) sequences, consisting of two independent trains of oscillating gradients which can have different orientations, in order to measure the time dependence of microscopic anisotropy in the mouse brain.

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