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Abstract #0278

Comparison of Double Diffusion Encoding and NODDI

Grant Kaijuin Yang1,2, Qiyuan Tian1,2, Christoph Leuze2, and Jennifer McNab2

1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States

In this study, we compare fractional eccentricity (FE) measured by double diffusion encoding (DDE) to NODDI estimates of neurite density and orientation distribution in six normal subjects and one subject with benign T2 hyperintensities. The results of the comparison support the hypothesis that FE is independent of fiber orientation and correlates strongly with intracellular volume fraction.

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