Abstract #0283

Multi-compartment microscopic diffusion imaging with oscillating gradients: simulation validation and application in multiple sclerosis patients

Hua Li^1,2, Enrico Kaden³, Daniel C. Alexander³, John C. Gore^1,2, Bagnato R. Francesca^1,2,4, and Junzhong Xu^1,2

¹Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ²Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, ³Centre for Medical Image Computing, University College London, United Kingdom, ⁴Neuroimmunology Division/Neuroimaging Unit, Department of Neurology, Vanderbilt University, Nashville, TN, United States

Microscopic diffusion imaging using spherical mean technique (SMT) and oscillating gradient spin echo (OGSE) was applied in multiple sclerosis patients, along with computer simulation validation. The results suggested that there are significant decreases of axon volume fraction in multiple sclerosis patients compared with contralateral normal tissue.

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