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Abstract #0283

Multi-compartment microscopic diffusion imaging with oscillating gradients: simulation validation and application in multiple sclerosis patients

Hua Li1,2, Enrico Kaden3, Daniel C. Alexander3, John C. Gore1,2, Bagnato R. Francesca1,2,4, and Junzhong Xu1,2

1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 2Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 3Centre for Medical Image Computing, University College London, United Kingdom, 4Neuroimmunology Division/Neuroimaging Unit, Department of Neurology, Vanderbilt University, Nashville, TN, United States

Microscopic diffusion imaging using spherical mean technique (SMT) and oscillating gradient spin echo (OGSE) was applied in multiple sclerosis patients, along with computer simulation validation. The results suggested that there are significant decreases of axon volume fraction in multiple sclerosis patients compared with contralateral normal tissue.

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