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Abstract #0284

Comparing in vivo MR g-ratio mapping methods: accuracy and precision at the group level

Isabel Ellerbrock1 and Siawoosh Mohammadi1,2,3

1Department of Systems Neuroscience, Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2UCL Institute of Neurology, University College London, London, United Kingdom, 3Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

The g-ratio, the ratio between the inner and outer diameter of a myelinated axon, is of great neuroscientific interest because it is a relative measure of axonal myelination and functionally linked to conduction velocity. In vivo g-ratio mapping has been recently suggested using a flexible biophysical model that relates the microscopic g-ratio, only accessible by histology, to MRI biomarkers for the myelin and fiber compartment. This study investigates the question which MRI biomarker is optimal for MR g-ratio mapping concerning precision (determined by scan-rescan reproducibility) and accuracy (assessed by comparability to previous in vivo and the ex vivo results).

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