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Abstract #0294

Post-surgical changes in aortic wall shear stress patterns in patients with aortopathy: a follow-up 4D flow MRI study

Emilie Bollache1, Paul W.M. Fedak2,3, Pim van Ooij4, Ozair Rahman1, Alex Hong1, Eric J. Keller1, S Chris Malaisrie3, Patrick M. McCarthy3, James C. Carr1, Jeremy D. Collins1, Michael Markl1,5, and Alex J. Barker1

1Department of Radiology, Northwestern University, Chicago, IL, United States, 2Department of Cardiac Sciences, University of Calgary, Calgary, AB, Canada, 3Division of Surgery-Cardiac Surgery, Northwestern University, Chicago, IL, United States, 4Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, 5Department of Biomedical Engineering, Northwestern University, Chicago, IL, United States

Our purpose was to follow up post-surgical changes in peak wall shear stress (WSS) and extent of at-risk tissue using 4D flow MRI in 34 aortopathy patients. Highly variable changes between pre- and post-surgery were found according to the intervention or replaced aortic valve type, while WSS patterns were unchanged in 20 other patients who did not undergo surgery. The reproducible 4D flow MRI WSS indices should be studied in larger cohorts and compared with patient outcome to potentially detect risk of future events in aortopathy patients, while optimizing the extent of resected aortic tissue.

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