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Abstract #0307

Imaging of the Tumor Type-specific Microenvironment in Preclinical Cancer Models of Varying Malignancy

Ellen Ackerstaff1, Natalia Kruchevsky1, Ekaterina Moroz1, H. Carl LeKaye1, Kristen L. Zakian1, SoHyun Han2, HyungJoon Cho2, Radka S. Stoyanova3, Nirilanto Ramamonjisoa1, Inna S. Serganova1, Ronald G. Blasberg1, and Jason A. Koutcher1

1Memorial Sloan-Kettering Cancer Center, New York, NY, United States, 2Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of, 3Miller School of Medicine, University of Miami, Miami, FL, United States

An abnormal tumor microenvironment characterized by hypoxia, low extracellular pH (pHe), vascular abnormalities, and high tumor lactate has been associated with aggressive, treatment-resistant tumors. Using tumor models of different origin and malignancy, and focusing on prostate cancer, we investigated the relationship of lactate metabolism and vascularity, and, in selected models, localized pHe. We found differences in whole-tumor lactate concentrations between tumor models and successfully mapped lactate concentrations. Vascular blood flow and permeability varied significantly between tumor models in well-vascularized areas, while being similar across all models in hypoxic areas, emphasizing a need for spatial characterization of the tumor microenvironment.

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