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Abstract #0308

Brain Tumors Disrupt the Resting-State Connectome

Darian Hadjiabadi1, Leland Pung1, Jiangyang Zhang2, BD Ward3, Woo-Taek Lim1, Meghana Kalavar2, Nitish V Thakor1, Bharat B Biswal4, and Arvind P Pathak1,2,5

1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Biophysics, The Medical College of Wisconsin, Milwaukee, WI, United States, 4Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States, 5Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Resting-state functional MRI (rsfMRI) has become indispensable for mapping the changes in ‘connectivity’ between brain regions in a range of diseases including brain tumors. However, the complex interplay between abnormal brain tumor vasculature, tumor blood flow, and cancer cell-induced neurovascular uncoupling can confound the interpretation of resting-state connectivity in patients. Therefore, in this preclinical study we quantified brain tumor-induced changes on resting-state connectivity relative to that in healthy brains, followed by histological validation. RsfMRI revealed that brain tumors alter the resting-state connectome, and histology confirmed that this was largely due to cancer cell-induced disruption of the neurovascular unit.

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