Abstract #0313

Correlated quantitative assessment of glioblastoma-angiogenesis by T2-mapping and in vivo multiphoton microscopy

Artur Hahn¹, Ke Zhang², Gergely Solecki^3,4, Michael O. Breckwoldt^1,5, Lukas R. Buschle^1,6, Sabine Heiland¹, Christian H. Ziener^1,6, Martin Bendszus¹, Frank Winkler^3,7, and Felix T. Kurz¹

¹Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany, ²German Cancer Research Center (DKFZ), Heidelberg, Germany, ³Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany, ⁴Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), Heidelberg, Germany, ⁵Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁶E010 Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁷Neurooncology (G370), German Cancer Research Center, Heidelberg, Germany

Microvasculatures in healthy cortical tissue, in untreated and in antiangiogenically treated glioblastoma multiforme are compared in a mouse model. From T2-maps, the information entropy is determined for each tissue type. In addition, capillaries are directly imaged through in vivo multiphoton microscopy to obtain sets of microvascular parameters. The T2-entropy is lowest in healthy tissue and significantly higher in glioblastoma, with a moderate decrease in treated tumors. Several vascular characteristics correlate with the T2-entropy. The correlations provide insight into the influence of microvasculature on MR-dephasing.

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