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Abstract #0313

Correlated quantitative assessment of glioblastoma-angiogenesis by T2-mapping and in vivo multiphoton microscopy

Artur Hahn1, Ke Zhang2, Gergely Solecki3,4, Michael O. Breckwoldt1,5, Lukas R. Buschle1,6, Sabine Heiland1, Christian H. Ziener1,6, Martin Bendszus1, Frank Winkler3,7, and Felix T. Kurz1

1Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany, 2German Cancer Research Center (DKFZ), Heidelberg, Germany, 3Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany, 4Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), Heidelberg, Germany, 5Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 6E010 Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 7Neurooncology (G370), German Cancer Research Center, Heidelberg, Germany

Microvasculatures in healthy cortical tissue, in untreated and in antiangiogenically treated glioblastoma multiforme are compared in a mouse model. From T2-maps, the information entropy is determined for each tissue type. In addition, capillaries are directly imaged through in vivo multiphoton microscopy to obtain sets of microvascular parameters. The T2-entropy is lowest in healthy tissue and significantly higher in glioblastoma, with a moderate decrease in treated tumors. Several vascular characteristics correlate with the T2-entropy. The correlations provide insight into the influence of microvasculature on MR-dephasing.

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