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Abstract #0315

Magnetisation Transfer MRI Facilitates Non-Invasive Identification of Fibrosis in Chemically-Induced Rat Mammary Carcinomas Imaged on a 1.5T Clinical Platform

Jessica KR Boult1, Neil P Jerome1, Matthew R Orton1, James d'Arcy1, Martin O Leach1, Dow-Mu Koh1,2, David J Collins1, and Simon P Robinson1

1CRUK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom, 2Department of Radiology, Royal Marsden NHS Foundation Trust, London, United Kingdom

Intratumoural fibrosis is associated with poor prognosis in breast cancer patients. Non-invasive detection of such fibrosis may contribute to the provision of personalised treatment regimens. Multi-parametric MRI, using a clinical MRI scanner and incorporating endogenous contrast mechanisms, was performed on MNU-induced rat mammary carcinomas to identify parameters sensitive to the detection and quantification of fibrosis. Magnetisation transfer MRI derived parameters correlated with percentage picrosirius red staining, which detects collagen I/III, major components of fibrosis, in this heterogeneous tumour cohort. These results strongly support the inclusion of magnetisation transfer in clinical MR breast imaging protocols.

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