Abstract #0316

MRI Tracking and Quantitative Analyzing Natural Killer Cell Infusion for Hepatocellular Carcinoma Treatment in a Rodent Model

Zhanliang Su^1,2, Xifu wang^2,3, Linfeng Zheng^2,3, Tianchu Lyu², Matteo Figini², Guohong Han⁴, Daniel Procissi², Lei Qin⁵, Bin Zhang⁵, Jeremy Shi Zhang², Wei Xing⁶, Yihe Yang², Kejiang Wang¹, Shixin Wang¹, Vahid Yaghmai^2,7, Andrew Christian Larson^2,7, and Zhuoli Zhang^2,7

¹Department of Radiology, Tianjin Xiqing Hospital, Tianjin, People's Republic of China, ²Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, ³Department of Radiology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China, ⁴Department of Liver Disease and Digestive Interventional Radiology, Xijing Hospital, Xi’an, United States, ⁵Department of Medicine, Division of Hematology/Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, ⁶Department of Radiology, Affiliated Third Hospital of Suzhou University, Changzhou, People's Republic of China, ⁷Robert H. Lurie Comprehensive Cancer Center

This paper presents the first evidence that transcatheter IHA NK cell local delivery for HCC adoptive transfer immunotherapy in a rat model.

We use a clinically feasible method by combining FDA-approved drugs heparin, protamine and ferumoxytol to compound HPF nanocomplexes for magnetic NK cell labeling so that their biodistribution can be visualized and quantized in vivo with MRI.

We demonstrated: a) transcatheter IHA NK cell infusion improved their homing efficacy to target tumors; b) quantitative analysis result of serial MRI monitoring of NK cell migrate to target tumors could serve as a key early biomarker for predicting longitudinal response.

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