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Abstract #0316

MRI Tracking and Quantitative Analyzing Natural Killer Cell Infusion for Hepatocellular Carcinoma Treatment in a Rodent Model

Zhanliang Su1,2, Xifu wang2,3, Linfeng Zheng2,3, Tianchu Lyu2, Matteo Figini2, Guohong Han4, Daniel Procissi2, Lei Qin5, Bin Zhang5, Jeremy Shi Zhang2, Wei Xing6, Yihe Yang2, Kejiang Wang1, Shixin Wang1, Vahid Yaghmai2,7, Andrew Christian Larson2,7, and Zhuoli Zhang2,7

1Department of Radiology, Tianjin Xiqing Hospital, Tianjin, People's Republic of China, 2Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 3Department of Radiology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China, 4Department of Liver Disease and Digestive Interventional Radiology, Xijing Hospital, Xi’an, United States, 5Department of Medicine, Division of Hematology/Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, 6Department of Radiology, Affiliated Third Hospital of Suzhou University, Changzhou, People's Republic of China, 7Robert H. Lurie Comprehensive Cancer Center

This paper presents the first evidence that transcatheter IHA NK cell local delivery for HCC adoptive transfer immunotherapy in a rat model.

We use a clinically feasible method by combining FDA-approved drugs heparin, protamine and ferumoxytol to compound HPF nanocomplexes for magnetic NK cell labeling so that their biodistribution can be visualized and quantized in vivo with MRI.

We demonstrated: a) transcatheter IHA NK cell infusion improved their homing efficacy to target tumors; b) quantitative analysis result of serial MRI monitoring of NK cell migrate to target tumors could serve as a key early biomarker for predicting longitudinal response.

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