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Abstract #0321

The Development And Prognostication Of Magnetic Resonance Elastography Thresholds In Primary Sclerosing Cholangitis

Kartik Jhaveri1, Hooman Hosseini-Nik, Nima Sadoughi, Harry Janssen, Jordan Feld, Sandra Fischer, Ravi Menezes, and Angela Cheung

1UHN, University of Toronto, Toronto, ON, Canada

Primary sclerosing cholangitis (PSC) is a chronic, progressive, cholestatic liver disease which causes bile duct structuring and eventually causes liver cirrhosis requiring liver transplantation. Due to heterogeneity of liver fibrosis distribution and lack of optimal method to assess disease severity accurate disease stratification is challenging. Magnetic resonance elastography (MRE) has shown very good results for quantification of hepatic fibrosis. MRE may provide a unique means of stratification and prognostication in PSC with its ability to assess a larger volume of hepatic tissue compared to biopsy or transient elastography(VCTE) and this what we explored in this prospective study.

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