Abstract #0322

Diffusion imaging detects differences in disease trajectory between two mouse models of pancreatic cancer

Palamadai Nilakantan Venkatasubramanian¹, Matthew Smith², Jesse Yan², Brian Hallis², Emman Mascarinas³, Andrew Diaz³, Brian DeCant³, Ron McKinney³, Paul J Grippo³, and Alice M Wyrwicz¹

¹Radiology, NorthShore University HealthSystem, Evanston, IL, United States, ²NorthShore University HealthSystem, Evanston, IL, United States, ³Medicine, University of Illinois at Chicago

Multiparametric MR microimaging deteced differences in pancreatic microstructure between two mouse models of pancreatic cancer, EL-KRASG12D (EK) and p48-Cre/LSL-Kras (KC) mice, that overexpress mutant KRas via different mechanisms. MR signatures characteristic of acinar-ductal metaplasia, fibrosis, cystic neoplasms and precancerous lesions revealed different trajectories of disease development between the two genetically engineered mice.

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