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Abstract #0327

NMR-based metabolomics and metabolic pathway networks from patient-matched colorectal cancers, adjacent non-cancerous tissues and fecal extracts

Yan Lin1, Changchun Ma2, Zhening Wang1, Jiahao Liang1, Yao Huang1, and Renhua Wu1

1Radiology department, Second Affiliated Hospital, Shantou University Medical College, Shantou City, People's Republic of China, 2Department of Radiation Oncology, Cancer Hospital, Shantou University Medical College, Guangdong Province, China, People's Republic of China

This study aimed to profile paralleled metabolites of CRC tissues and adjacent non-cancerous tissues alongside pre- and post-operative stools from the same patients, to investigate how fecal metabolomic phenotypes correlate with the tumor tissue especially in a molecular pathology context. Our patient-matched cohort revealed a few overlapping discriminatory metabolites between the CRC and stool metabolomes, indicating the networks for metabolic pathway aberrations across both matrices. The altered metabolites potentially involved in the disruption of normal bacterial ecology, malabsorption of nutrients, increased glycolysis, TCA cycle and glutaminolysis, implying a Warburg effect for cell energy production required for rapid proliferation

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