Abstract #0328

Hyperpolarized Micro-NMR for Metabolic Flux Analysis in Cancer Stem Cells and Rapid Assessment of Therapeutic Response

Sangmoo Jeong¹, Roozbeh Eskandari¹, Sun Mi Park², Ralph Weissleder^3,4, Michael G. Kharas^2,5, Hakho Lee^3,4, and Kayvan R. Keshari^1,5

¹Department of Radiology/Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²Center for Cell Engineering/Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ³Center for Systems Biology, Massachusetts General Hospital, Boston, MA, United States, ⁴Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁵Weill Cornell Medical College, New York, NY, United States

Aberrant metabolic features of cancer cells are closely related to tumorigenesis and therapeutic response. Here, we report a sensitive magnetic resonance sensing platform, capable of analyzing metabolic fluxes in mass-limited samples. Termed hyperpolarized micromagnetic resonance spectrometer (HMRS), this platform achieved to characterize the metabolic flux in cancer stem cells in real-time and assess therapeutic responses much earlier than any changes in cell viability. This will become a versatile platform for rapid and sensitive exploration of metabolic dynamics in cancer.

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