Abstract #0341

Association between Age of Intraplaque Hemorrhage and Fibrous Cap Rupture in Carotid Artery Atherosclerosis: A High Resolution Magnetic Resonance Imaging Study

Yuanyuan Cui¹, Xihai Zhao², Huiyu Qiao², Dongxiang Xu³, Mingming Lu¹, Xiaoyi Chen^2,4, Lu Ma¹, and Jianming Cai¹

¹Department of Radiology, The General Hospital of People’s Liberation Army (301 hospital), Beijing, People's Republic of China, ²Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, People's Republic of China, ³Department of Radiology, University of Washington, Seattle, United States, ⁴Beijing Institute for Brain Disorders, Capital Medical University, Beijing, People's Republic of China

It has been shown that presence of carotid artery intraplaque hemorrhage (IPH) is associated with fibrous cap rupture (FCR), which is one of the major causes of ischemic cerebrovascular events. However, the role of different age of IPH in occurrence of IPH remains unclear. This study investigated the association between the age of IPH and FCR in carotid arteries using MR imaging. We found that fresh IPH volume was independently associated with FCR (odds ratio: 1.826; 95% CI: 1.130-2.949; P=0.014). Compared with recent IPH, fresh IPH was a stronger predictor for FCR (area under the curve: 0.79 vs. 0.64).

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