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Abstract #0341

Association between Age of Intraplaque Hemorrhage and Fibrous Cap Rupture in Carotid Artery Atherosclerosis: A High Resolution Magnetic Resonance Imaging Study

Yuanyuan Cui1, Xihai Zhao2, Huiyu Qiao2, Dongxiang Xu3, Mingming Lu1, Xiaoyi Chen2,4, Lu Ma1, and Jianming Cai1

1Department of Radiology, The General Hospital of People’s Liberation Army (301 hospital), Beijing, People's Republic of China, 2Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, People's Republic of China, 3Department of Radiology, University of Washington, Seattle, United States, 4Beijing Institute for Brain Disorders, Capital Medical University, Beijing, People's Republic of China

It has been shown that presence of carotid artery intraplaque hemorrhage (IPH) is associated with fibrous cap rupture (FCR), which is one of the major causes of ischemic cerebrovascular events. However, the role of different age of IPH in occurrence of IPH remains unclear. This study investigated the association between the age of IPH and FCR in carotid arteries using MR imaging. We found that fresh IPH volume was independently associated with FCR (odds ratio: 1.826; 95% CI: 1.130-2.949; P=0.014). Compared with recent IPH, fresh IPH was a stronger predictor for FCR (area under the curve: 0.79 vs. 0.64).

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