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Abstract #0347

Long-term Cerebrovascular Dysfunction Following Repeated Mild Traumatic Brain Injury

Conner Adams1,2, Margaret Koletar1, Tina L. Beckett1, Lindsay Cahill3, Lydiane Hirschler4,5,6, Jan M. Warnking4,6, Emmanuel L. Barbier4,6, JoAnne McLaurin1,7, John G. Sled2,3, and Bojana Stefanovic1,2

1Sunnybrook Research Institute, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Mouse Imaging Centre, The Hospital For Sick Children, Toronto, ON, Canada, 4Grenoble Institut des Neurosciences, UniversiteĢ Grenoble Alpes, Grenoble, France, 5Bruker Biospin MRI, Ettlingen, Germany, 6Inserm, U1216, Grenoble, France, 7Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

Pseudo-Continuous Arterial Spin Labelling (pCASL) was used to assess cerebrovascular dysfunction of mice having traumatic brain injury (TBI) - which had been induced via serial controlled cortical impacts. Resting perfusion was quantified in absolute units via multiple post-label-delay pCASL experiments, and found to be reduced in the lesion. Furthermore, vascular reactivity to hypercapnic challenge, assessed via pCASL, appears to be enhanced in initial results. These results, in conjunction with immunohistochemical analysis and T2-weighted structural images, imply severe damage due to TBI, with vascular adaptation in the form of angiogenesis as the response from the brain.

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Abstract