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Abstract #0348

Comparative Study of 3D Arterial Spin Labeling and dynamic contrast-enhanced MRI of Nasopharyngeal Carcinoma perfusion imaging

Bohan Xiao1, Zhaoxiang Ye1, Peiguo Wang1, Ying Liu1, Yingyu Zhao1, and Dandan Zheng2

1Key Laboratory of Cancer Prevention and Therapy, Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People's Republic of China, 2MR Research China, GE Healthcare, Beijing, People's Republic of China

DCE-MRI is already a standard approach to evaluating tumor perfusion in NPC, but it may induce severe side-effects. ASL is a noninvasive MRI technique that has been mainly used to achieve perfusion imaging in central nerve system. In this study, we attempt to evaluate the application of ASL in NPC. Thirty-eight newly diagnosed NPC patients underwent 3D ASL and DCE-MRI perfusion scans on a 3.0-T MRI system. ASL BF value and DCE-MRI parameters were calculated and compared. Statistically significant correlation was found between them. Therefore, 3D ASL may provide a potential alternative to DCE-MRI in NPC diagnosis and therapy evaluation.

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