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Abstract #0349

Non-contrast vascular compliance mapping using time-resolved VASO CBV imaging

Yang Li1,2, Deng Mao1,2, Jay J. Pillai1, and Hanzhang Lu1

1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Graduate School of Biomedical Sciences, UT Southwestern Medical Center, Dallas, TX, United States

Vascular compliance reflects the stiffness of arterial vessel wall and has been related to a number of diseases, such as cardiovascular disease, cerebral arteriosclerosis, and hypertension. However, the vascular compliance at intracranial arteries has been rarely measured due to limited availability of effective methods. In this work, a 3D VASO-CBV-based MR technique was developed to assess the arterial CBV change with respect to pulsation and thus estimate vascular compliance. With this technique, we were able to map vascular compliance along the intracranial arterial tree.

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