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Abstract #0354

A Novel Approach to Measuring Cerebral Oxygen Extraction Fraction and Vascular Reserve Using MRI

Charles Cantrell1, Yong Jeong2, Kevin Midlash3, Parmede Vakil2, Sameer Ansari2, and Timothy J Carroll3

1Northwestern University, Chicago, IL, United States, 2Northwestern University, 3University of Chicago

The length scales associated with parenchymal oxygen extraction fraction (OEF), coupled with the near uniformity of normative OEF across the brain dictate the development of an imaging approach that is sensitive to low-spatial frequency imaging behavior. Previous approaches to measure OEF using MRI have utilized high pass-filters—effectively removing much of the signal. We propose a new method to filter out geometric field inhomogeneity, by imaging temporally through the cardiac cycle. In a study in 11 patients with intracranial atherosclerotic disease, we found elevated OEF on the compromised hemisphere as compared to the healthy contralateral side (p<0.0195).

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