Abstract #0353

Changes in cerebral blood flow and default mode network connectivity following mTBI observed with pulsed arterial spin labeling

Natalie M. Wiseman¹, Armin Iraji², E. Mark Haacke^2,3, and Zhifeng Kou^2,3

¹Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States, ²Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States, ³Department of Radiology, Wayne State University, Detroit, MI, United States

Mild traumatic brain injury (mTBI) or concussion disturbs both cerebral blood flow (CBF) and functional connectivity in intrinsic connectivity networks (ICNs). Using pulsed arterial spin labeling (PASL), we derived both CBF and ICNs in mTBI patients and investigated brain CBF responses to network disruptions. We observed that mTBI patients have decreased connectivity within the default mode network (DMN) in two regions as well as increased CBF in a third region which overlaps the DMN. The mismatch of these regions suggests potential repair or compensation for injury.

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