Abstract #0356

Simultaneous cerebral blood flow and bold oxygen level dependent signal assessments using multi-band multi-echo pseudo-continuous arterial spin labeling (M2-PCASL)

Shiyang Chen¹, Junjie Wu², Kyle Pate², Xiaodong Zhong^2,3, Bruce Crosson^2,4, and Deqiang Qiu²

¹Georgia Institute of Technology, Atlanta, GA, United States, ²Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, ³MR R&D Collaborations, Siemens Healthcare, Atlanta, GA, United States, ⁴Department of Neurology, Emory University, Atlanta, GA, United States

We proposed a novel multi-band multi-echo pseudo-continuous arterial spin labeling (M2-PCASL) method to simultaneously measure the cerebral blood flow (CBF) and the blood oxygen level dependent (BOLD) signal. Increased spatial resolution was achieved compared to the conventional method, and experiments were also conducted to show simultaneous measurement of CBF and BOLD signal dynamics in response to hypercapnia. M2-PCASL can be a useful tool for measuring cerebrovascular reactivity and studying neurovascular coupling in various conditions.

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