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Abstract #0362

Robust agreement between MRI and MRS hepatic proton density fat fraction despite biologically plausible variability in fat spectra in patients with nonalcoholic steatohepatitis

Cheng William Hong1, Adrija Mamidipalli1, Jonathan C Hooker1, Gavin Hamilton1, Tanya Wolfson2, Soudabeh Fazeli Dehkordy1, Scott B Reeder3, Rohit Loomba4, and Claude B Sirlin1

1Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, CA, United States, 2Computational and Applied Statistics Laboratory, University of California, San Diego, San Diego, CA, United States, 3Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin, Madison, Madison, WI, United States, 4NAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California, San Diego, San Diego, CA, United States

MRI- and MRS-based proton density fat fraction (PDFF) techniques require accurate modeling of the multi-peak spectrum of triglycerides (TG) in order to achieve accurate hepatic fat quantification. However, variations in TG spectrum may lead to quantification variability. We performed a secondary analysis of adults with biopsy-confirmed nonalcoholic steatohepatitis undergoing confounder-corrected chemical-shift-encoded 3T MRI and MRS, and calculated variant PDFF values using a range of biologically plausible spectral models. Within the range of fat fractions seen in the liver, PDFF estimation using MRI and MRS was robust to variability in the TG spectrum. Greater bias was seen when the baseline fat fraction was higher, but remained low.

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