Abstract #0362

Robust agreement between MRI and MRS hepatic proton density fat fraction despite biologically plausible variability in fat spectra in patients with nonalcoholic steatohepatitis

Cheng William Hong¹, Adrija Mamidipalli¹, Jonathan C Hooker¹, Gavin Hamilton¹, Tanya Wolfson², Soudabeh Fazeli Dehkordy¹, Scott B Reeder³, Rohit Loomba⁴, and Claude B Sirlin¹

¹Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, CA, United States, ²Computational and Applied Statistics Laboratory, University of California, San Diego, San Diego, CA, United States, ³Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin, Madison, Madison, WI, United States, ⁴NAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California, San Diego, San Diego, CA, United States

MRI- and MRS-based proton density fat fraction (PDFF) techniques require accurate modeling of the multi-peak spectrum of triglycerides (TG) in order to achieve accurate hepatic fat quantification. However, variations in TG spectrum may lead to quantification variability. We performed a secondary analysis of adults with biopsy-confirmed nonalcoholic steatohepatitis undergoing confounder-corrected chemical-shift-encoded 3T MRI and MRS, and calculated variant PDFF values using a range of biologically plausible spectral models. Within the range of fat fractions seen in the liver, PDFF estimation using MRI and MRS was robust to variability in the TG spectrum. Greater bias was seen when the baseline fat fraction was higher, but remained low.

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