Abstract #0363

Free-breathing Fat Quantification in the Liver Using a Multiecho 3D Stack-of-Radial Technique: Investigation of Motion Compensation and Quantification Accuracy

Tess Armstrong^1,2, Thomas Martin^1,2, Alto Stemmer³, Xinzhou Li^1,4, Yutaka Natsuaki⁵, Kyunghyun Sung^1,2, and Holden H. Wu^1,2

¹Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ²Physics and Biology in Medicine, University of California Los Angeles, Los Angeles, CA, United States, ³Siemens Healthcare GmbH, Erlangen, Germany, ⁴Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, ⁵Siemens Healthcare, Los Angeles, CA, United States

Multiecho Cartesian MRI methods can non-invasively quantify liver fat, but are susceptible to motion artifacts and limited by breath-hold (BH) imaging. We have developed a new free-breathing (FB) liver fat quantification technique using 3D stack-of-radial imaging (Radial). In this work, we further investigate motion compensation and quantification accuracy for FB Radial. In n=11 healthy volunteers, FB Radial fat quantification demonstrated significant correlation (ρ > 0.9876) and low mean difference (< -1.19%) compared to BH Cartesian and BH single-voxel spectroscopy. FB Radial can potentially achieve accurate whole-liver fat quantification with either a fast 1-2 minute scan or a 3-minute self-navigated scan.

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