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Abstract #0365

Monitoring Resolution of Fatty Liver Disease with MRI following Bariatric Surgery: A Prospective, Multi-center Study

B. Dustin Pooler1, Curtis Wiens1, Alan McMillan1, Nathan Artz2, Alexandra Schlein3, Yesenia Covarrubias3, Jonathan Hooker3, Jeffrey Schwimmer3, Luke Funk1, Guilherme Campos4, Jacob Greenberg1, Garth Jacobsen3, Santiago Horgan3, Claude B. Sirlin3, and Scott B. Reeder1

1University of Wisconsin, Madison, WI, United States, 2St. Jude Children's Research Hospital, Memphis, TN, 3University of California-San Diego, San Diego, CA, 4Viginia Commonwealth University, Richmond, VA

The temporal resolution of fatty liver disease following bariatric surgery is poorly understood. We used a validated chemical shift encoded MRI (CSE-MRI) method to measure liver proton density fat fraction (PDFF) as a biomarker of liver fat. We followed a cohort of 50 obese adults undergoing bariatric surgery with pre-operative very low calorie diet (VLCD) and conclude that average liver PDFF normalizes to <5% by 6 months following bariatric surgery. Normalization of liver fat is seen in 79% of patients who lower body mass index (BMI) by ≥10 mg/k2 and 83% of patients who lose ≥30 kg.

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