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Abstract #0378

Advances in Angle Sensitive MRI: Towards in vivo analysis of collagen fibre tracts in the Anterior Cruciate Ligament

Karyn E Chappell1, Quentin Herreros2, Donald W McRobbie3, and Djordje Brujic4

1Surgery and Cancer, Imperial College London, London, United Kingdom, 2Institut de Physique Nucléaire de Lyon, Lyon, France, 3Medical Physics & Radiation Safety, Flinders Medical Centre, Adelaide, Australia, 4Mechanical Engineering, Imperial College London, London, United Kingdom

There is great interest in collagen MR imaging due to its non-invasive nature. To be able to detect early structural changes in collagen the main magnetic field must move around the patient.

A new rotatable MR system enabling in vivo Angle Sensitive MRI was designed and its prototype has been built. Key elements of the new method are: optimisation of scanning directions, collagen orientation distribution computation and fibre tract reconstruction.

We have proved that nine scans in optimal directions achieve satisfactory accuracy. Previous Angle Sensitive MRI times are almost halved whilst analysis time is shortened by more than 100 times.

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