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Abstract #0379

Collagen fiber to magnetic field angle dependence in human meniscus – a preliminary T2* MR-microscopy study at 7T

Benedikt Hager1,2, Sonja Walzer3, Vladimir Juras1,4, Martin Zalaudek1, Xeni Deligianni5, Oliver Bieri5, Andreas Berg6, Joachim Friske1, Markus Schreiner3, Reinhard Windhager3, and Siegfried Trattnig1,2

1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3Department of Orthopaedic Surgery, Medical University of Vienna, Vienna, Austria, 4Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 5Department of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland, 6Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria

We evaluated the fiber-to-field dependence of a meniscal specimen using T2* mapping on high-field 7T MRI in combination with an MR microimaging insert and validated the results with histology. We found that, different structures of the meniscus behave very differently with orientation to the magnetic field. For example, short T2/T2* tendon-like structure located in the external circumference showed strongest T2* dependence reflecting the anisotropic nature of these structures and consequential incomplete averaging of dipolar coupling. The results shown here are the first MR Microscopy evaluations of the orientational dependence of T2* relaxation in human meniscus.

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