Abstract #0380

The magic angle effect can (partially) explain load-induced increases in meniscal T2 and T1ρ

Valentina Mazzoli^1,2,3, Danny Tsui², Larry de Graaf², Klaas Nicolay², Andre M Sprengers³, Dennis Janssen³, Nico Verdonschot³, Aart J Nederveen¹, and Gustav J Strijkers⁴

¹Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, ²Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ³Orthopaedic Research Lab, Radboud UMC, Nijmegen, Netherlands, ⁴Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands

Often, knee injury and disorders are caused by or lead to abnormal biomechanical loading patterns in the knee joint menisci. Quantitative information on in vivo loading patterns is therefore in high demand to evaluate therapy and prevent further damage. T_1ρ and T₂ in meniscus were shown to increase upon application of compressive load, although the mechanisms leading to changes remain unclear. In this work we apply compressive load on the meniscus of volunteers and one cadaver and show that compression-induced internal fiber reorganization may manifest as the magic angle effect, which may be responsible for load-induced T₂ and T_1ρ increases.

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