Abstract #0394

Cerebral Arteries Hemodynamics in Alzheimer's Disease Assessed by Phase-Contrast Velocity Mapping

Reyes García de Eulate¹, Irene Goñi², Alvaro Galiano¹, Marta Vidorreta³, Miriam Recio⁴, Mario Riverol⁴, Jose Luis Zubieta¹, and María Fernández-Seara^1,2

¹Radiology, University of Navarra Hospital, Pamplona, Spain, ²Biomedical Engineering, TECNUN, University of Navarra, San Sebastian, Spain, ³Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, United States, ⁴Neurology, University of Navarra Hospital, Pamplona, Spain

Vascular disease increases the risk of Alzheimer's disease. The assessment of vascular dysfunction in subjects at risk for AD has the potential to contribute to the disease early diagnosis and management. In this work, the phase-contrast velocity mapping MRI technique was used to evaluate cerebral hemodynamics in patients with cognitive dysfunction and healthy controls. Results showed significant differences in hemodynamic parameters (velocity and flow) across groups with lower mean values in the AD and MCI groups compared to the CO group. PC-MRI can be used to assess hypoperfusion in an early stage of AD.

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