Abstract #0395

Association of cerebral blood flow and amyloid burden in autosomal dominant Alzheimer’s disease

Lirong Yan¹, Collin Liu², Koon-Pong Wong³, Sung-Cheng Huang³, John Ringman², and Danny JJ Wang¹

¹Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, ²Neurology, University of Southern California, Los Angeles, CA, United States, ³University of California Los Angeles, United States

The purpose of this study was to investigate the association of cerebral blood flow alternation with cerebral amyloid deposition in autosomal dominant Alzheimer’s disease. Cross-subject negative correlation between cerebral blood flow and amyloid deposition was observed, indicating brain regions with high amyloid deposition may be associated with hypoperfusion. Our finding suggests cerebral hypoperfusion may contribute to the onset and progression of AD.

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