Abstract #0396

Association of vascular risk factors with cerebral metabolic rate

Kevin King¹, Min Sheng², Peiying Liu³, Christopher Maroules⁴, Craig Rubin⁵, Ron Peshock⁶, Roderick McColl⁷, and Hanzhang Lu⁸

¹Huntington Medical Research Institutes, Pasadena, CA, United States, ²Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ³Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Radiology, UT Southwestern Medical Center, Dallas, TX, ⁵Geriatrics, UT Southwestern Medical Center, Dallas, TX, United States, ⁶Radiology, Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, ⁷Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ⁸Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Vascular risk factors that confer a susceptibility for dementia are thought to result in silent brain changes decades before disease onset. We hypothesized that vascular risk factors would be associated decreased Cerebral Metabolic Rate of Oxygen consumption (CMRO₂). CMRO₂ was derived from Arterial Spin Labelling cerebral blood flow (CBF) and oxygen extraction fraction (OEF) from TRUST MRI in this IRB approved study with informed consent on 70 participants. In stepwise linear regression higher diastolic blood pressure was correlated with decreased CMRO₂ but was not associated with CBF, suggesting mechanisms other than insufficient blood flow underlie the association with metabolic rate.

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