Abstract #0398

Cross-sectional and Longitudinal Cerebral Blood Flow Changes in the Progression from Normal Cognition to Alzheimer’s Disease Measured with Continuous Arterial Spin Labeling (CASL)

Wenna Duan¹, H. Michael Gach², Arvind Balachandrasekaran³, Parshant Sehrawat¹, Ashish B. Bhumkar¹, Paresh B. Boraste¹, James T. Becker⁴, Oscar L. Lopez⁵, and Weiying Dai¹

¹Department of Computer Science, Binghamton University (SUNY), Binghamton, NY, United States, ²Department of Radiation Oncology, Washington University, Saint Louis, St. Louis, MO, United States, ³Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, United States, ⁴Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United States, ⁵Department of Psychiatry and Neurology, University of Pittsburgh, Pittsburgh, PA, United States

Cross-sectional and longitudinal analysis of cerebral blood flow (CBF) versus cognitive status were performed in an elderly cohort. Voxel-based ANOVA was used to test the CBF difference between normal control (NC), mild cognitive impairment (MCI) and Alzheimer’s Disease (AD) groups at the baseline. Eight significant clusters were found between groups. The longitudinal CBF change in each cluster was compared across 4 longitudinal groups (stable NC, NC-to-MCI, stable MCI, and MCI/AD-to-AD) using a multiple linear regression model. The results indicated that CBF rises in AD-related regions of the brain during MCI and then drops dramatically in advanced MCI or early AD.

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