Abstract #0399

Effects of transactive response DNA-binding protein 43 (TDP43) pathology on amygdala volume and shape, in a community cohort of older adults

Nazanin Makkinejad¹, Junxiao Yu¹, Aikaterini Kotrotsou¹, Arnold M. Evia¹, Julie A. Schneider^2,3,4, Sue E. Leurgans^2,3, David A. Bennett^2,3, and Konstantinos Arfanakis^1,2,5

¹Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States, ³Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States, ⁴Department of Pathology, Rush University Medical Center, Chicago, IL, United States, ⁵Department of Diagnostic Radiology, Rush University Medical Center, Chicago, IL, United States

TDP43 pathology is now recognized as a common and deleterious neuropathology of the aging brain. TDP43 pathology typically originates in the amygdala, which is, however, commonly affected by other age-related neurodegenerative pathologies. The purpose of this work was to investigate the effects of TDP43 pathology on the volume and shape of the amygdala in a large community cohort of older adults.

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