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Abstract #0399

Effects of transactive response DNA-binding protein 43 (TDP43) pathology on amygdala volume and shape, in a community cohort of older adults

Nazanin Makkinejad1, Junxiao Yu1, Aikaterini Kotrotsou1, Arnold M. Evia1, Julie A. Schneider2,3,4, Sue E. Leurgans2,3, David A. Bennett2,3, and Konstantinos Arfanakis1,2,5

1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States, 3Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States, 4Department of Pathology, Rush University Medical Center, Chicago, IL, United States, 5Department of Diagnostic Radiology, Rush University Medical Center, Chicago, IL, United States

TDP43 pathology is now recognized as a common and deleterious neuropathology of the aging brain. TDP43 pathology typically originates in the amygdala, which is, however, commonly affected by other age-related neurodegenerative pathologies. The purpose of this work was to investigate the effects of TDP43 pathology on the volume and shape of the amygdala in a large community cohort of older adults.

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