Abstract #0400

Fixel-based analysis of Alzheimer's Disease using multi-tissue constrained spherical deconvolution of multi-shell diffusion MRI

Diana L. Giraldo^1,2, Hanne Struyfs ³, David A. Raffelt⁴, Paul M. Parizel⁵, Sebastiaan Engelborghs^3,6, Eduardo Romero², Jan Sijbers¹, and Ben Jeurissen¹

¹Vision Lab, Department of Physics, University of Antwerp, Antwerp, Belgium, ²Computer Imaging and Medical Applications Laboratory, Universidad Nacional de Colombia, Bogota, Colombia, ³Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium, ⁴Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, ⁵Department of Radiology, University of Antwerp, Antwerp, Belgium, ⁶Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium

In this study, we used multi-shell, multi-tissue constrained spherical deconvolution to investigate group differences in white matter between control subjects, patients with mild cognitive impairment (MCI) due to Alzheimer's Disease (AD) and patients with dementia due to AD. Using the recently proposed fixel-based analysis approach, we distinguish between different fibre populations within a single voxel and characterize them with 3 measures: fibre density, fibre cross-section and the product of these two. We found significant decreases of these metrics in MCI and AD patients compared to healthy controls.

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