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Abstract #0403

Glutamate modulation during working memory task performance:  A functional proton magnetic resonance spectroscopy study in healthy adult volunteers

Eric Andrew Woodcock1, Chaitali Anand1, Jonathan Lynn1, Dalal Khatib1, and Jeffrey A Stanley1

1Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States

Glutamate is involved in excitatory neurotransmission and oxidative metabolism. In vivo glutamate measurements at task-relevant temporal resolution are possible using functional proton magnetic resonance spectroscopy. The present study quantified glutamate levels in the dorsolateral prefrontal cortex during working memory task performance and interspersed periods of rest. Results demonstrated that our approach was feasible and quantification of glutamate levels was reliable at 32s temporal resolution. Statistical analyses demonstrated that glutamate levels were elevated during working memory task performance (relative to rest), consistent with our hypotheses. Elevated glutamate levels during task performance likely reflect increased oxidative metabolism due to excitatory neurotransmission.

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