Abstract #0404

Dynamic changes of glutamate detected by functional MR spectroscopy in human visual cortex in regions with positive and negative BOLD response

Miguel Martínez-Maestro¹, Christian Labadie², Ioannis Angelos Giapitzakis³, and Harald E. Möller¹

¹Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ²Berlin Center for Advanced Neuroimaging, Charité Universitätsmedizin, Berlin, Germany, ³Max Planck Institute for Biological Cybernetics, Tuebingen, Germany

Dynamic changes of metabolite concentrations have been presented in human visual cortex in response to stimulus that induce a positive BOLD response (PBR). The present study compares the metabolic profile of the positive and the negative bold response (NBR). The application of different fMRS block designs showed a significant increase in Glutamate (+7.3%) during the PBR stimulation paradigm in agreement with previous studies and a decrease (-6.6%) during the NBR, which provides new information about its underlaying mechanisms.

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