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Abstract #0404

Dynamic changes of glutamate detected by functional MR spectroscopy in human visual cortex in regions with positive and negative BOLD response

Miguel Martínez-Maestro1, Christian Labadie2, Ioannis Angelos Giapitzakis3, and Harald E. Möller1

1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Berlin Center for Advanced Neuroimaging, Charité Universitätsmedizin, Berlin, Germany, 3Max Planck Institute for Biological Cybernetics, Tuebingen, Germany

Dynamic changes of metabolite concentrations have been presented in human visual cortex in response to stimulus that induce a positive BOLD response (PBR). The present study compares the metabolic profile of the positive and the negative bold response (NBR). The application of different fMRS block designs showed a significant increase in Glutamate (+7.3%) during the PBR stimulation paradigm in agreement with previous studies and a decrease (-6.6%) during the NBR, which provides new information about its underlaying mechanisms.

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