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Abstract #0405

Activation induced changes in GABA: functional MRS at 7T with MEGA-sLASER

Chen Chen1, Hilmar P. Sigurdsson 2, Sophia E. Pépés2, Dorothee P. Auer3, Penny A. Gowland1, Paul S. Morgan3, and Stephen R. Jackson2

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2School of Psychology, University of Nottingham, Nottingham, United Kingdom, 3School of Medicine, University of Nottingham, Nottingham, United Kingdom

To investigate changes in GABA levels in human motor cortex in response to the hand clenching task, the macromolecule-corrected MEGA-sLASER sequence was used in functional MRS (fMRS) experiments conducted at 7T. During motor activation, the total creatine (tCr) signal remained stable, while a significant transient increase in GABA/tCr (20%±11%) was observed. The measured increase in Glx/tCr (12%±6%) was higher but consistent with changes reported for Glutamate. With consistent editing performance for GABA detection and the advantage of visually identifying GABA peaks in spectra, this spectral editing approach showed its potential for future fMRS studies of GABA.

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