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Abstract #0406

Detection of Changes in the Creatine Kinase Cycle Rate in the Human Visual Cortex During Visual Stimulation with  Filter Exchange 1H MR Spectroscopy (FEXSY) at 7T

Casper Wolf1, Andrew Webb2, and Itamar Ronen2

1Vrije Universiteit, Amsterdam, Netherlands, 2Radiology, Leiden University Medical Center, Leiden, Netherlands

We selectively monitored the Cr/PCr exchange rate during visual stimulation using filter exchange spectroscopy (FEXSY), a pulse sequence sensitized to exchange between two pools with different diffusion coefficients. A Significant difference was observed between the filtered and non-filtered D(tCr) during rest, and vanished during stimulation, indicating an increase in the rate of creation of a fast-diffusing species in the tCr complex during stimulation. This suggests an increased production of Cr from PCr resulting from increased metabolic demand, or an increase in “free” vs. enzyme-bound tCr. The non-filtered ADC of NAA significantly increased during activation, suggesting microstructural change during activation.

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