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Abstract #0407

Dynamics of lactate levels measured by functional proton magnetic resonance imaging in the rat somatosensory cortex upon increasing electrical hindpaw stimuli.

Aline Seuwen1, Aileen Schroeter1, and Markus Rudin1,2

1Institute for Biomedical Engineering, University & ETH Zürich, Zürich, Switzerland, 2Institute of Pharmacology and Toxicology, University of Zurich

MRSI in mice reveals changes in glutamate and lactate levels in somatosensory brain areas elicited by electric hindpaw stimulation. Using increasing stimulus amplitudes, lactate signals consistently decreased with increasing stimulus strength. This surprising result might reflect accelerated lactate clearance triggered by a generalized CBF increase in response to hindpaw stimulation, previously observed in this species. In contrast to mice, Lac levels in the contralateral somatosensory cortex of rats significantly increased with stimulus amplitude reflecting increased glycolytic activity and no obvious indication of increased lactate clearance. Despite the difference in Lac responses, similar Glu responses have been observed in both species.

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