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Abstract #0408

Apparent diffusion coefficients of the five major metabolites in the human brain at 3 T

Dinesh K Deelchand1, Edward J Auerbach1, and Małgorzata Marjańska1

1CMRR, University of Minnesota, Minneapolis, MN, United States

The goal of this study was to measure the apparent diffusion coefficients (ADC) of five main metabolites in the human brain at 3 T using PRESS and STEAM sequences where measurement biases due to cross-terms were avoided by using positive and negative diffusion gradient polarity. This study shows that comparable trace/3 ADC values for total N-acetyl aspartate, total creatine, total choline, glutamate and myo-inositol can be successfully measured with both acquisition methods on a clinical scanner with STEAM providing slightly better quantification precision for J-coupled metabolites.

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