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Abstract #0409

Diffusion-Weighted Echo Planar J-resolved Spectroscopic Imaging

Manoj K Sarma1, Zohaib Iqbal1, Andres Saucedo1, Paul M Macey2, and M. Albert Thomas1

1Radiological Sciences, UCLA School of Medicine, Los Angeles, CA, United States, 2School of Nursing, UCLA School of Medicine, Los Angeles, CA, United States

Diffusion weighted spectroscopy enables investigation of brain intracellular microstructure in-vivo. Here we implemented a novel technique called diffusion-weighted echo-planar J-resolved spectroscopic imaging (DW-EPJRESI) which is capable of giving information about metabolite diffusivity beyond NAA, Cr and Cho in multiple brain locations simultaneously. The technique was evaluated in a brain phantom and four healthy volunteers. Highly reproducible diffusion-weighted metabolite maps were obtained. The ADC values were in good agreement with previous reported values. Further optimization of the DW-EPJRESI sequence will become more practical for clinical use.

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