Abstract #0410

Probing alterations of cellular metabolism and structure in CNTF-induced mouse model of astrocytic activation using in vivo MRS and diffusion-weighted MRS

Clemence Ligneul¹, Marco Palombo¹, Edwin Hernandez Gazon¹, Martine Guillermier¹, Sueva Bernier¹, Kelly Ceyzeriat¹, Laurene Abjean¹, Julien Flament^1,2, Carole Escartin¹, and Julien Valette¹

¹Molecular Imaging Research Center (MIRCen), Commissariat à l'Energie Atomique (CEA), Fontenay aux Roses, France, ²UMS 27, INSERM, Fontenay aux Roses, France

In this work we use in vivo MRS and diffusion-weighted MRS (DW MRS) on a model of astrocytic activation induced by the ciliary neutrophic factor (CNTF) in mice striatum. We observe a massive metabolic remodeling in CNTF mice in comparison with control mice. We demonstrate the intrinsic potential of DW MRS to detect alterations in cellular structure by measuring substantial variations in diffusion properties of astrocytic and neuronal metabolites. Modeling suggests significantly larger astrocytic processes, consistently with astrocytic hypertrophy as observed by microscopy in the context of activation.

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