Abstract #0411

Comparison diffusion behavior of metabolites in brains of congenital portal systemic shunt and healthy mice in vivo at 14.1T

Masoumeh Dehghani¹, Nicolas Kunz², Rolf Gruetter^1,2,3, and Hongxia Lei^2,3

¹Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Center for Biomedical Imaging(CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ³Department of Radiology, University of Geneva, Geneva, Switzerland

The aim of this study was to determine whether diffusion behavior of metabolites in the congenital portal systemic shunt(PSS) mouse brain is different from ones of the healthy controls in vivo, combining large diffusion weighting and ¹H MRS methods. The diffusion behavior of most investigated metabolites except taurine was in excellent agreement with those in control mouse brain. The reduced diffusivities of taurine in PSS mice compared to control ones may be due of possible cellular redistribution of taurine in response to some osmotic perturbations in PSS mice in vivo, however, it needs to be further explored.

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