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Abstract #0412


Bhavana Shantilal Solanky1, Ferran Prados 2, Carmen Tur1, Sebastien Ourselin2, Xavier Golay3, Olga Ciccarelli1, and Claudia A M Gandini Wheeler-Kingshott1,4,5

1UCL Institute of Neurology, Queen Square MS Centre, University College London, London, United Kingdom, 2Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 3UCL Institute of Neurology, University College London, London, United Kingdom, 4Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 5Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy

Increased sodium concentration in the normal appearing brain of multiple sclerosis (MS) patients has recently been reported, which may be a consequence of axonal loss or an accumulation of intracellular sodium. Here we investigated spinal cord total sodium concentrations in MS patients and healthy controls. Spinal cord atrophy, as a result of axonal loss, often presents in MS, therefore we also tested for the association of sodium with SC area. We found increased total sodium levels in the SC, but no correlation with the decrease in SC cross sectional area in the MS cohort.

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