Abstract #0419

Column-specific demyelination in Spinal Cord Normal Appearing White Matter occurring in Multiple Sclerosis: A preliminary study using inhomogeneous Magnetization Transfer and DTI

Henitsoa RASOANANDRIANINA^1,2,3, Bertrand AUDOIN^1,4, Olivier GIRARD^1,2, Guillaume DUHAMEL^1,2, Sarah DEMORTIERE⁴, Maxime GUYE^1,2, Jean-Philippe RANJEVA^1,2, Jean PELLETIER^1,4, and Virginie CALLOT^1,2,3

¹Aix Marseille Univ, CNRS, CRMBM, Marseille, France, ²AP-HM, Pôle d'Imagerie Médicale, Hopital de La Timone, CEMEREM, Marseille, France, ³iLab-Spine International Associated Laboratory, Marseille, France, ⁴Aix Marseille Univ, APHM, Hopital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France

This preliminary study investigates the added value of the inhomogeneous Magnetization Transfer (ihMT) technique when studying Spinal Cord (SC) tissue demyelination occurring in Multiple Sclerosis (MS). DTI and MT/ihMT data collected in 9 MS patients, analyzed in specific normal appearing white matter regions, indicated significant demyelination in corticospinal and posterior sensory tracts as compared to age-matched healthy controls, with a very high sensitivity of ihMTR that appears very promising for further objective therapeutic evaluation or topographic quantification of progressive SC demyelination.

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