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Abstract #0420

Comparative Myelin Imaging and Multi-Shot Diffusion Tensor Imaging in Multiple Sclerosis Cervical Spinal Cord

Hagen H Kitzler1, Hannes Wahl1, Gesine Pach1, Judith C Eisele2, Katja Thomas2, Sean Deoni3, Tjalf Ziemssen2, and Jennifer Linn1

1Neuroradiology, Technische Universit├Ąt Dresden, Dresden, Germany, 2Neurology, Technische Universit├Ąt Dresden, Dresden, Germany, 3Pediatric Radiology Research, Children's Hospital, Colorado, University of Colorado Medical School, Boulder, CO, United States

Spinal cord myelin imaging holds potential to quantify cervical spinal cord tissue myelin loss, and hence, the subtle spinal burden of demyelinating diseases, invisible for conventional magnetic resonance imaging. We present the approach of combined spinal 3D double-inversion recovery imaging with diffusion tensor imaging and myelin sensitive multicomponent driven equilibrium single pulse observation of T1 and T2, with subsequent normal spine space registration and group comparison in different multiple sclerosis courses. Whereas no significant differences were found between the different disease courses using fractional anisotropy, relapsing-remitting and primary-progressive multiple sclerosis were discriminated based on differences in relative cord myelin content.

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