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Abstract #0428

Assessment of liver function using an uptake ratio based on multiple-time points  hepatocyte mapping

Tomoyuki Okuaki1, Kosuke Morita2, Tomohiro Namimoto3, Morikatsu Yoshida3, Shinya Shiraishi3, Yasuyuki Yamashita3, and Marc Van Cauteren1

1MR Clinical Science, Philips Healthtech, Tokyo, Japan, 2Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan, 3Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

We calculated the uptake fraction (kHep) based on a pharmacokinetics model of gadolinium ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) uptake using R1 changes in the hepatocyte. The kHep and ΔT1 values were compared to indexes determined by 99mTc-GSA scintigraphy for three different scan time points. The correlation coefficients of the blood clearance indexes (HH15) and receptor indexes (LHL15) were 0.307 and 0.497 for the ΔT1 and 0.537 and 0.570 for kHep values, respectively. The results indicate that the proposed quantification value of kHep is a more robust index for liver function compared with the ΔT1 value.

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