Abstract #0428

Assessment of liver function using an uptake ratio based on multiple-time points hepatocyte mapping

Tomoyuki Okuaki¹, Kosuke Morita², Tomohiro Namimoto³, Morikatsu Yoshida³, Shinya Shiraishi³, Yasuyuki Yamashita³, and Marc Van Cauteren¹

¹MR Clinical Science, Philips Healthtech, Tokyo, Japan, ²Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan, ³Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

We calculated the uptake fraction (k_Hep) based on a pharmacokinetics model of gadolinium ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) uptake using R1 changes in the hepatocyte. The k_Hep and ΔT1 values were compared to indexes determined by 99mTc-GSA scintigraphy for three different scan time points. The correlation coefficients of the blood clearance indexes (HH15) and receptor indexes (LHL15) were 0.307 and 0.497 for the ΔT1 and 0.537 and 0.570 for k_Hep values, respectively. The results indicate that the proposed quantification value of k_Hep is a more robust index for liver function compared with the ΔT1 value.

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