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Abstract #0429

Detection of Advanced Liver Fibrosis and Cirrhosis using MR elastography compared to liver surface nodularity measurement, EOB-DTPA uptake and blood tests

Cecilia Besa1, Mathilde Wagner1,2, Grace Lo1, Sonja Gordic1, Manjil Chatterji1, Ashley Stueck3, James Babb4, Andrew Smith5, and Bachir Taouli1

1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Radiology, Groupe Hospitalier Pitié Salpêtrière, Paris, France, 3Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Radiology, New York University Langone Medical Center, New York, United States, 5Radiology, University of Mississippi Medical Center, Jackson, MS, United States

This study compares the diagnostic performance of multiparametric MRI including qualitative and quantitative assessment of MR-elastography (MRE), liver surface nodularity (LSN) software measurement, hepatic enhancement ratios on Gd-EOB-DTPA (EOB-ER), and serum markers (APRI and FIB4) for the detection of liver fibrosis and cirrhosis. When comparing different MRI methods and serum markers with histologic findings, liver stiffness measured with MRE showed better performance than other methods for detection of advanced liver fibrosis and cirrhosis, especially when combined with blood tests (FIB4).

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